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KMID : 0363420210350030118
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Journal of Korean Oriental Pediatrics
2021 Volume.35 No. 3 p.118 ~ p.127
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ECS Modulating Effect of Scutellaria baicalensis Extract on inflammation relief in atopic dermatitis-induced mice
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Ahn Sang-Hyun
Kim Ki-Bong
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Abstract
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Objective The purpose of this study was to confirm the effect of Scutellaria baicalensis extract on skin damage recovery and inflammation relief in atopic dermatitis-induced mice through Endocannabinoid system (ECS) control.
Methods 6-week-old Balb/C mice were divided into control group (Ctrl), atopic dermatitis induced group (ADE), palmitoylethanolamide (PEA) administered group after atopic dermatitis induced (PEAT), and Scutellaria baicalensis extract administered group after atopic dermatitis induced (SBT). Seven animals were assigned for each group. After drug administration for 3 weeks after inducing atopic dermatitis, Claudin and 8-OHdG were observed to confirm the recovery of the skin damage in each group. To confirm ECS regulation, CB1, CB2, and GPR55 were observed.
To confirm the anti-inflammatory effect, Fc ε receptor, and MMP-9 was observed.
Results Claudin positive reaction was significantly increased in SBT compared to ADE and PEAT. 8-OHdG positive reaction was significantly decreased in SBT compared to ADE and PEAT. CB1, CB2, and GPR55 positive responses were significantly increased in SBT compared to ADE and PEAT. Fc ε receptor and MMP-9 positivity were significantly decreased in SBT compared to ADE and PEAT.
Conclusion It was confirmed that the Scutellaria baicalensis extract can reduce the inflammation of atopic dermatitis by restoring the structural damage of the skin lipid barrier through ECS activity.
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KEYWORD
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Scutellaria baicalensis, Atopic dermatitis, Endocannabinoid system (ECS), Fc ε recetor
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